[Weitergeleitet aus Robin Monotti Channel Featuring Mike Yeadon]
„ADE can arise in several different ways but the best-known is dubbed the ‘Trojan Horse Pathway’. This occurs when non-neutralizing antibodies generated by past infection or vaccination fail to shut down the pathogen upon re-exposure.
Instead, they act as a gateway by allowing the virus to gain entry and replicate in cells that are usually off limits (typically immune cells, like macrophages). That, in turn, can lead to wider dissemination of illness, and over-reactive immune responses that cause more severe illness.
Barry Bloom, MD, PhD, of the Harvard T.H. Chan School of Public Health explanation of ADE is as follows –
“The cause of ADE is having antibodies to a virus that don’t neutralize it. That enables the virus to be gobbled up by cells that have receptors for antibodies, but not the virus. That’s the way of getting virus into cells that it ordinarily would not infect,”.
ADE can also occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don’t protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness“